I used to play online every day during the poker boom. Micro-stakes NLHE cash, low-stakes limit Hold'em, and occasional mixed games and STTs/MTTs.
After the big sites all got shut down, that was the end of it for me. I'm comfortable risking money at poker, but also risking it against the possibility of the site getting torn down and me having to beg the government for my online roll back? No thanks.
Now that public online poker has been around for a while and is slimmed down to mostly serious players, we're coming up on the additional problem of adept, systematic cheating (as opposed to sloppy opportunistic cheating from weak players). We have been coming across this on and off for years now, actually, and the number of cases that have been exposed should alarm anyone who plays online, since they likely only represent a fraction of total cheating instances.
It's bad enough for collusion to be so easy to carry out undetected. That's the main form of cheating I would expect to arise out of a game where the players can communicate so freely while in-game. But this new trend of "solvers" is going to be the death knell for online poker unless it is somehow brought under control. This GlitchSystem guy exposed himself by being greedy, but he may well have been able to go undetected for a long time at lower stakes, while still making bank.
The technology is out there to make poker not a matter of consistently beating a game through skill, but a matter of simply investing in profitable tools and exploiting them. Most serious players care enough about the game to not destroy it like that, but as soon as you have software that tells you what to do, there's no need for actual poker players to be involved anymore. Some entrepreneur could set up a bank of "dream machines" and hire people to milk games all day long. If the technology gets stealthy enough, it could even be done with bots instead of humans. For all we know, it's happening already to some degree. The tech is out there, and we don't know who else has it.