Fewer denominations are better, especially in no limit when having to count stacks. Spacing denominations 4x-5x apart limits unnecessary extra denominations.
I would rather count a stack with 42 singles and 5 quarters, rather than 1 ten, 3 fives, 18 singles and 1 quarter. Both will total 43.25, but you will get the answer in the first stack faster than the second, even though the second stack is far fewer chips, is four denominations, meaning you have to sum four figures in your head instead of two. I am sure every here is smart enough to sum four figures, but if it's a question of ease, two is always easier.