My suspicion is that you won't be able to play the kind of game you'd like to play while keeping these players.I play poker because I like the skill aspect, but playing with these players is more often straight gambling, which is much less fun for me.
I'm not sure what to do to maintain a healthy game at this point with the players I have. I've been hosting less frequently and going to a game that's a bit of a drive for me but doesn't have any drama. There are likely some more players in my area that would play 25c/50c if it actually played at those stakes but they are inconsistent, whereas the big gamblers come everytime I host but are clearly playing larger than the blinds suggest.
They want to play Any Two Cards. Raising the blinds, changing the buy-in rules, switching to pot-limit, etc won't change that; it'll only frustrate them and make them go broke faster. You could try to teach them how to play skillful poker, but they probably aren't interested.
Consider closing your game, playing at other people's games for a while, and then later starting over with a clean slate. Invite players who play the style that you want to see in your game.