Personally, I would just ditch the .25 or .50 chips and play 1/1. I switched from .50/1 to 1/1 and it was just much easier. I did $60-$200 buy-in.
20 x $1
16-36 x $5
My old set breakdown for this was like:
200 x $1
400 x $5
200 x $25
If you are going to use .25 chips though, I don't think you need more than 8 per player. And much like casino 2/5 games, i'd say that non-dollar increments of .25 chips don't count as part of your stack except for posting blinds. Meaning you can only bet in $1 increments outside of posting the small blind.